≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
内毒素
< 0.5 EU per mg protein.
生物活性
Testing in progress
蛋白构建
A DNA sequence encoding the mouse IL2RB (P16297) (Met1-Glu240) was expressed with a C-terminal polyhistidine tag.
表达宿主
HEK293 Cells
种属
Mouse
预测 N 端
Ala 27
分子量
The recombinant mouse IL2RB comprises 225 amino acids and has a predicted molecular mass of 26.5 kDa.
缓冲液
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
运输方式
It is supplied and shipped as liquid with dry ice.
稳定性 & 储存条件
Samples are stable for up to twelve months
from date of receipt at -20℃ to -80℃. Store it under sterile conditions
at -20℃ to -80℃. It is recommended that the protein be aliquoted for
optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant Mouse IL-2R beta/CD122 Protein (His Tag), HPLC-verified, Endotoxin-Free: 别称
Interleukin-2 receptor (IL-2R) also
known as High-affinity IL-2 receptor subunit beta, IL-2 receptor subunit
beta, and IL-2RB, is involved in T cell-mediated immune responses.
CD122/IL-2RB is present in 3 forms concerning the ability to bind
interleukin 2. The low-affinity form is a monomer of the alpha subunit
and is not involved in signal transduction. The intermediate affinity
form consists of an alpha/beta subunit heterodimer, while the
high-affinity form consists of an alpha/beta/gamma subunit heterotrimer.
Both the intermediate and high-affinity forms of CD122/IL-2RB are
involved in receptor-mediated endocytosis and transduction of mitogenic
signals from interleukin 2. CD122/IL-2RB expression was restricted to
the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that
proliferate vigorously to IL-2 in the absence of any stromal cells, but
not to IL-15. The high-affinity form of this receptor is expressed on
activated T lymphocytes, activated B lymphocytes, and activated
macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte
development.
