< 1.0 EU per μg protein as determined by the LAL method.
生物活性
Testing in progress
蛋白构建
A DNA sequence encoding the rat IL2RB (NP_037327.1) (Met1-Glu239) was expressed with a polyhistidine tag at the C-terminus.
Accession#
NP_037327.1
表达宿主
HEK293 Cells
种属
Rat
预测 N 端
Ala 27
分子量
The recombinant rat IL2RB consists 224 amino acids and predicts a molecular mass of 26.4 kDa.
缓冲液
Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk
packages of recombinant proteins are provided as frozen liquid. They
are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months
from date of receipt at -20℃ to -80℃. Store it under sterile conditions
at -20℃ to -80℃. It is recommended that the protein be aliquoted for
optimal storage. Avoid repeated freeze-thaw cycles.
复溶
To find reconstitution info, click on 'COA'
at the top of the page, enter the lot number and product size for the
lot-specific COA.
Recombinant Rat IL-2R beta/CD122 Protein (His Tag): 别称
Il2rb Protein, Rat; IL2RBC Protein, Rat
IL-2R beta/CD122 背景信息
Interleukin-2 receptor (IL-2R) also
known as High-affinity IL-2 receptor subunit beta, IL-2 receptor subunit
beta, and IL-2RB, is involved in T cell-mediated immune responses.
CD122/IL-2RB is present in 3 forms concerning the ability to bind
interleukin 2. The low-affinity form is a monomer of the alpha subunit
and is not involved in signal transduction. The intermediate affinity
form consists of an alpha/beta subunit heterodimer, while the
high-affinity form consists of an alpha/beta/gamma subunit heterotrimer.
Both the intermediate and high-affinity forms of CD122/IL-2RB are
involved in receptor-mediated endocytosis and transduction of mitogenic
signals from interleukin 2. CD122/IL-2RB expression was restricted to
the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that
proliferate vigorously to IL-2 in the absence of any stromal cells, but
not to IL-15. The high-affinity form of this receptor is expressed on
activated T lymphocytes, activated B lymphocytes, and activated
macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte
development.
