Recombinant Mouse IL-2R gamma/CD132 Protein (His & hFc Tag)

概述

产品介绍

Cat No. IL-2-PM1204

库存：现货

Size

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产品介绍

纯度

> 92 % as determined by SDS-PAGE

内毒素

< 1.0 EU per μg of the protein as determined by the LAL method

生物活性

Testing in progress

蛋白构建

A DNA sequence encoding the extracellular domain (Met 1-Ala 263) of mouse IL2RG (NP_038591.1) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Accession#

NP_038591.1

表达宿主

HEK293 Cells

种属

Mouse

预测 N 端

Trp 23

分子量

The recombinant mouse IL2RG/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 489 amino acids and has a predicted molecular mass of 56.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm IL2RG/Fc monomer is approximately 75-85 kDa due to glycosylation.

缓冲液

Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

运输方式

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

稳定性 & 储存条件

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

复溶

To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA.

Recombinant Mouse IL-2R gamma/CD132 Protein (His & hFc Tag): 别称

CD132 Protein, Mouse; gamma(c) Protein, Mouse; gc Protein, Mouse; Il2rg Protein, Mouse; p64 Protein, Mouse; [g]c Protein, Mouse

IL-2R gamma/CD132 背景信息

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

全称

interleukin 2 receptor, gamma

相关通路图

Common G-Chain signaling pathway

参考文献

Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.