The common gamma chain (γc) (or CD132),
also known as interleukin-2 receptor subunit gamma or IL2RG, is a member
of the type I cytokine receptor family expressed on most lymphocyte
(white blood cell) populations, and its gene is found on the
X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a
cytokine receptor subunit that is common to the receptor complexes for
at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9,
IL-15, and the interleukin-21 receptor. It is a component of multiple
cytokine receptors that are essential for lymphocyte development and
function. X-linked severe combined immunodeficiency (X-SCID) is a rare
and potentially fatal disease caused by mutations of IL2RG, the gene
encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4
receptor based on chemical cross-linking data, the ability of IL2RG to
augment IL-4 binding affinity. The observation that IL-2R gamma is a
functional component of the IL-4 receptor, together with the finding
that IL-2R gamma associates with the IL-7 receptor, begins to elucidate
why a deficiency of this common gamma chain (gamma c) has a profound
effect on lymphoid function and development, as seen in X-linked severe
combined immunodeficiency.
全称
interleukin 2 receptor, gamma
参考文献
Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
Miyazaki T, et al.
(1994) Functional activation of Jak1 and Jak3 by selective association
with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.
