Recombinant Human IL-2R gamma/CD132 Protein (His Tag), HPLC-verified, Endotoxin-Free

概述

产品介绍

Cat No. IL-2-PH1111

库存：现货

Size

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产品介绍

纯度

≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

内毒素

< 0.5 EU per mg protein.

生物活性

Testing in progress

蛋白构建

A DNA sequence encoding the human IL2RG (NP_000197.1) (Met1-Ala262) was expressed with a polyhistide tag at the C-terminus.

表达宿主

HEK293 Cells

种属

Human

预测 N 端

Leu 23

分子量

The recombinant human IL2RG consists of 251 amino acids and predicts a molecular mass of 29.72 kDa.

缓冲液

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

运输方式

It is supplied and shipped as liquid with dry ice.

稳定性 & 储存条件

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant Human IL-2R gamma/CD132 Protein (His Tag), HPLC-verified, Endotoxin-Free: 别称

CD132 Protein, Human; CIDX Protein, Human; IL-2RG Protein, Human; IMD4 Protein, Human; P64 Protein, Human; SCIDX Protein, Human; SCIDX1 Protein, Human

IL-2R gamma/CD132 背景信息

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

全称

interleukin 2 receptor, gamma