IL7, also known as interleukin 7, is a
hematopoietic growth factor that belongs to the IL-7/IL-9 family. It is
secreted by stromal cells in the bone marrow and thymus. IL7 stimulates
the proliferation of lymphoid progenitors. It is important for
proliferation during certain stages of B-cell maturation. IL7 and the
hepatocyte growth factor (HGF) form a heterodimer that functions as a
pre-pro-B cell growth-stimulating factor. It is found to be a cofactor
for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T
cell development. IL7 can be produced locally by intestinal epithelial
and epithelial goblet cells and may serve as a regulatory factor for
intestinal mucosal lymphocytes.
参考文献
Watanabe M, et al.
(1995) Interleukin 7 is produced by human intestinal epithelial cells
and regulates the proliferation of intestinal mucosal lymphocytes.
J Clin Invest. 95(6):2945-53. Sawa Y, et al. (2009) Hepatic interleukin-7 expression regulates T cell responses. Immunity. 30 (3):447-57.
Flad HD, et al.
(1996) Human follicular dendritic cells and vascular cells produce
interleukin-7: a potential role for interleukin-7 in the germinal center
reaction. Eur J Immunol. 26(10): 2541-4.
